- Casino
- By State
- Alabama
- Alaska
- Arizona
- Arkansas
- California
- Colorado
- Connecticut
- Delaware
- Georgia
- Florida
- Hawaii
- Idaho
- Illinois
- Indiana
- Iowa
- Kansas
- Kentucky
- Louisiana
- Maine
- Massachusetts
- Maryland
- Michigan
- Minnesota
- Mississippi
- Missouri
- Montana
- Nebraska
- Nevada
- New Hampshire
- New Jersey
- New Mexico
- New York
- North Carolina
- North Dakota
- Ohio
- Oklahoma
- Oregon
- Pennsylvania
- Rhode Island
- South Carolina
- South Dakota
- Tennessee
- Texas
- Utah
- Vermont
- Virginia
- Washington
- West Virginia
- Wisconsin
- Wyoming
- By State
- Slots
- Poker
- Sports
- Esports
NFL Week 4: Seahawks vs 49ers, Time, Odds

Things are heating up in NFC West, where the LA Rams and the Arizona Cardinals are still undefeated. The two meet on Sunday, meaning that one of them will get to 3-1.
That’s good news for the San Francisco 49ers (2-1), who could get to 3-1 with a win in Week 4. The bad news for them is that they’re taking on another NFC West team, the Seattle Seahawks.
Even though the Seahawks are 1-2 at the moment, they surely have plenty of talent on the roster. Evidence of this is that they beat the Niners both times in 2020.
Seahawks vs 49ers Odds (NFL Week 4, 2021)
All odds are per DraftKings as of September 27.
Moneyline
Seattle Seahawks | +170 |
San Francisco 49ers | -200 |
Spread
Seattle Seahawks +3.5 | -110 |
San Francisco 49ers -3.5 | -110 |
Over/Under
Over 50 | -110 |
Under 50 | -110 |
Where and When to Watch
Date: Sunday, October 3
Time: 04:25 PM EDT
Location: Levi’s Stadium in San Francisco, CA
Watch: FOX
The Seahawks Need to Work on Their Defense
Seattle leads the all-time series against San Francisco 28-17, with 15 of those wins happening since Russel Wilson’s been their quarterback. Furthermore, they won eight of the past ten games against the Niners, including the two played in the 2020 NFL season.
In Week 4 of the 2021 season, it’s San Francisco that’s seen as the favorite. The reason isn’t just that the Niners have been playing relatively well so far; it’s also because the Seahawks’ defense has been horrendous.
After beating the Colts 28-16 in Indianapolis in Week 1, the Seahawks lost the next two games. First, they lost to the Tennessee Titans at home 33-30 in overtime. Then, they lost to the Minnesota Vikings 30-17 in Minnesota.
The final score sure looks bad, but it could’ve been even worse. The Seahawks looked anemic against Kirk Cousins, whom we saw making three TD passes in the first half.
The Seahawks offense didn’t do much better either. They started reasonably well with ten points in the first quarter and seven in the second. However, they scored zero points in the other half of the game.
The Niners Want to Bounce Back After Heart-Breaking Loss in Week 3
The Niners had a one-point lead until the very last second of the game against the Green Bay Packers, but then placekicker Mason Crosby scored a field goal.
Nevertheless, San Francisco players should feel proud of their performance against one of the best offenses in the league. They should also feel optimistic ahead of Week 4, as they’re now taking on a team that doesn’t seem as lethal as the Packers.
The Seahawks did score a lot of points against the Niners in 2020 (60 in two games), but this time, San Francisco’s defense looks much stronger. After all, this year, they got Nick Bosa in the team. One of the NFL’s best edges had to miss 14 games in 2020 due to an injury, but this season, he’s back and he’s been phenomenal thus far.
Pick: San Francisco 49ers to win and cover the spread; we shouldn’t see too many points.
Jessie, our resident sports specialist, brings over 5 years of experience in sports journalism to our team. She has worked with several prominent online sports news outlets, gaining specialist insight across a wide range of sports markets. Her passion for sports is evident, having competed at a national level during college. Jessie aims to enhance the value of our sports coverage for readers at Gambling News with her expertise and enthusiasm.
Must Read
Sports
February 10, 2025
Utah Jazz vs. Los Angeles Lakers 2025 NBA Odds, Time, and Prediction
More Articles
Sports
February 14, 2025
Iowa Doesn’t Want You to Use Proxy Betting, or Face Consequences
Sports
February 12, 2025
Real Madrid’s Dramatic Win Cost bet365 Millions
Sports
February 12, 2025
Nevada Sportsbooks Reach Record Super Bowl Profit Despite Lower Handle
Sports
February 11, 2025
Allwyn Joins Formula 1 as Official Partner, Vows to Empower Fans
Sports
February 11, 2025
FanDuel Recorded 16.6 Million Super Bowl Bets
Sports
February 11, 2025
Mavericks Governor Dumont Criticizes Dončić’s Work Ethic
Sports
February 11, 2025
Eagles’ Super Bowl Blowout Gives Sportsbooks a Win
Sports
February 10, 2025
William Hill Sponsors Spring Festivals Trials Day at Naas Racecourse
Sports
February 7, 2025
Donald Trump Could Be Professional Golf’s New Messiah