- Casino
- By State
- Alabama
- Alaska
- Arizona
- Arkansas
- California
- Colorado
- Connecticut
- Delaware
- Georgia
- Florida
- Hawaii
- Idaho
- Illinois
- Indiana
- Iowa
- Kansas
- Kentucky
- Louisiana
- Maine
- Massachusetts
- Maryland
- Michigan
- Minnesota
- Mississippi
- Missouri
- Montana
- Nebraska
- Nevada
- New Hampshire
- New Jersey
- New Mexico
- New York
- North Carolina
- North Dakota
- Ohio
- Oklahoma
- Oregon
- Pennsylvania
- Rhode Island
- South Carolina
- South Dakota
- Tennessee
- Texas
- Utah
- Vermont
- Virginia
- Washington
- West Virginia
- Wisconsin
- Wyoming
- By State
- Slots
- Poker
- Sports
- Esports
Rams vs 49ers NFL Week 10 Odds, Time and Prediction

The San Francisco 49ers had a fantastic chance to win their fourth game of the season last Sunday. They played against the undermanned Arizona Cardinals at home but ended up losing 37-17. The bad news for them is that they have a much tougher challenge coming their way on Monday night when super-motivated LA Rams come to town.
The Rams are 7-2 on the season, with a loss in Week 9 to the Tennessee Titans. With a win on Monday, they would challenge the #1 position in the NFC West, which is currently occupied by the Cards.
Rams vs 49ers Odds (NFL Week 10, 2021)
All odds are per DraftKings as of November 8.
Moneyline
Los Angeles Rams | -190 |
San Francisco 49ers | +160 |
Spread
Los Angeles Rams -4.5 | +100 |
San Francisco 49ers +4.5 | -120 |
Over/Under
Over 49.5 | -110 |
Under 49.5 | -110 |
Where and When to Watch
- Date: Monday, November 15
- Time: 8:15 pm ET
- Location: Levi’s Stadium, San Francisco, CA
- Watch: ESPN
Los Angeles Rams Determined to Win the MNF Game
The Rams have nothing to worry about in the playoffs, as even if they don’t win the NFC West, they will almost certainly get a Wild Card entry. Still, they do have a decent chance to win the division, as they currently have only one win fewer than the Cardinals.
These guys probably feel disappointed for not winning the Week 9 game against the Titans, who were without their arguably best player Derrick Henry in that game. The Rams lost 28-16, but that probably isn’t going to affect their morale too much. They know that they have a fantastic roster, so getting back on the winning track shouldn’t be a problem.
This goes especially for the fact that they’re taking on their divisional rivals, who have been very disappointing this season. Another incentive for the Rams is that they have a bad record against the Niners, especially in the past couple of years. In fact, they lost to San Francisco in each of their previous four meetings.
Out-of-Form Niners Worried About Their Future
The Niners have lost five of their previous six games. The most recent of those is a defeat to the Cardinals on Sunday. It’s strange that the Niners lost that game, especially because the final score was 31-17 for the Cardinals, who were without several key players.
The Niners’ defense was horrible against the Cards, who couldn’t do anything to stop the Cardinals’ backup quarterback Colt McCoy. Their offense didn’t score much, but their QB was pretty decent. The man in question is Jimmy Garoppolo, who went 28/40 for 326 yards and two touchdowns.
Their rushing game was horrible against the Cardinals and will probably be horrible in Week 10. The reason is that the Rams’ defensive players are experts at stopping the opposition rushes. Unfortunately for the Niners, their next opponents are also great in passing defense. No surprise there, as their cornerbacks are Jalen Ramsey and Darious Williams.
For all these reasons, anything but a convincing win for the visiting team would be a huge surprise. The Rams are coming to San Francisco to destroy their divisional rivals.
Pick: Los Angeles Rams to win and cover the spread; over should hit.
Jessie, our resident sports specialist, brings over 5 years of experience in sports journalism to our team. She has worked with several prominent online sports news outlets, gaining specialist insight across a wide range of sports markets. Her passion for sports is evident, having competed at a national level during college. Jessie aims to enhance the value of our sports coverage for readers at Gambling News with her expertise and enthusiasm.
Must Read
Sports
September 11, 2025
Magomed Ankalaev vs. Alex Pereira UFC 320 Odds, Time, and Prediction
Sports
September 11, 2025
Merab Dvalishvili vs. Cory Sandhagen UFC 320 Odds, Time, and Prediction
Sports
September 11, 2025
Jiri Prochazka vs. Khalil Rountree UFC 320 Odds, Time, and Prediction
More Articles
Sports
September 16, 2025
Texas Sees Surge in Sports Betting via DFS and Prediction Apps
Sports
September 16, 2025
Better Collective Introduces AI Betting Tool to Keep Users Engaged
Sports
September 16, 2025
Prediction Markets Face Legal Uncertainty as US States and Courts Weigh In
Sports
September 16, 2025
Washington Warns Gambling Among Teenagers Is on the Rise
Sports
September 15, 2025
Massachusetts Sues Kalshi Over Alleged Unlawful Sports Betting
Industry
September 15, 2025
Curaçao Regulator Takes BC.Game License Revocation Off Public List
Industry
September 15, 2025
Lawmakers Try Again to End Federal Sports Betting Tax
Sports
September 12, 2025
Finland’s Floorball League Rocked by Wagering Scandal
Sports
September 12, 2025
NCAA Investigating 13 More College Players for Betting Violations
Sports
September 12, 2025
HK Makes History Approving Bill to Legalize Basketball Betting
Sports
September 11, 2025
NBA Keeps Looking Into Malik Beasley After Questionable Betting Trends
Sports
September 10, 2025
Newcastle vs. Barcelona Champions League Odds, Time, and Prediction